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U.S. Department of Health and Human Services


The use of chemical, biological, radiological, nuclear or high-yield explosive (CBRNE) devices has the potential to cause mass casualties and high levels of destruction. When preparing for or responding to emergencies involving CBRNE agents, it is critical for medical personnel and other responders to have immediate access to the best available information and resources.

ASPR CBRNE Science is an innovative means to bringing experiential, evidence-basis, and science and medicine to preparedness and response to CBRNE incidents.  CBRNE Science brings together experts that understand both the science and operations to provide leadership decision support, operational guidance, and emergency management support.  CBRNE Science employs an incubator approach that utilizes small teams, working groups, and task groups on a day-to-day basis to collaboratively inform CBRNE response solutions and, as needed, actual response activities and leadership decisions. 

This approach has led to the development of guidance and resources; better understanding of response capabilities; and enhanced domestic and global preparedness through education, information, and expert support.  In response to an accidental or intentional CBRNE incident domestically or internationally, CBRNE Science provides coordinated strategic, technical, and operational leadership, advice, and guidance for all levels of the medical response regarding medical and public health impacts and interventions.


Improve overall of public health emergency preparedness by:

  • Providing medical and health-related CBRNE subject matter and operational expertise across the spectrum of ASPR preparedness and response;
  • Recognizing, anticipating and evaluating gaps in the Nation’s medical and public health response systems; and
  • Working through cooperative professional interactions to develop innovative, evidence-based interventions that strengthen the Nation’s medical and public health emergency response.


The nation’s health and response systems and communities will be prepared, responsive and resilient to limit the adverse health impacts of CBRNE emergencies.

What We Do

  • Expertise and Collaboration – CBRNE Science coordinates SMEs and provides a unique linkage and node for technical and operational expertise to inform the activities of ASPR and other partner efforts. Experts also participate in exercises, deployments, and other response activities.
  • Resources and Guidance – By applying evidence-based decision making to preparedness planning, the CBRNE Science develops innovative, novel approaches and guidance to improve understanding of the best ways to prepare for, respond to and recover from a CBRNE incident. The goal is to ensure that the best science is incorporated to develop feasible, multi-use, collaborative resources and guidance.
  • Implementation and Outreach – To enhance national preparedness, CBRNE Science utilizes a strategic approach and tools for outreach, integration, and implementation of the plans, concepts, guidance, and resources. This approach is integrated with the ASPR Regional Emergency Coordinator (REC) program and the requirements of partners, and stakeholders. CBRNE Science is also the ASPR focal point for such operational capabilities as the Radiation Injury Treatment Network (RITN).

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  • This page last reviewed: January 08, 2018