Bamlanivimab/etesevimab Baseball Card

Etesevimab Injection (700 mg/20 mL)

MUST ADMINISTER WITH BAMLANIVIMAB

Manufacturer: Eli Lilly and Company Distributor: AmerisourceBergen (a.k.a., ABC); c19therapies@amerisourcebergen.com Product: Component of 2-drug monoclonal antibody cocktail for outpatient infusion Emergency Use Authorization (EUA): 02/09/2021 Units:Supplied as one single-dose 20 mL vial per carton Earliest Expiration Date of Units Shipped: 12/6/2021

Storage: Keep in carton until use. Unopened vials must be stored at refrigerated temperature (2oC to 8oC/36°F–46°F) until use. Do not freeze, shake, or expose to direct light.

Single Vial w/ Carton Dimensions: 1.7”(d) x 1.8”(w) x 2.7”(h)
Single Vial w/ Carton Weight: 2.1 oz.

Case: A full case contains 100 vials in cartons
Case Dimensions: 9.3”(d) x 18.9”(w) x 6.3”(h)
Case Weight: 13.3 lb.

Bamlanivimab Injection (700 mg/20 ml)

Manufacturer: Eli Lilly and Company Distributor: AmerisourceBergen (a.k.a., ABC); c19therapies@amerisourcebergen.com Product: Component of 2-drug monoclonal antibody cocktail for outpatient infusion & Single monoclonal antibody for outpatient infusion Emergency Use Authorization (EUA): 02/09/2021 (2-drug cocktail); 11/9/2020 (single agent) Units: Supplied as one single-dose 20-ml vial per carton Earliest Expiration Date of Units Shipped: 9/9/2021

Storage: Keep in carton until use. Unopened vials must be stored at refrigerated temperature (2oC–8oC / 36°F–46°F) until use. Do not freeze, shake, or expose to direct light.

Earliest Expiration Date of Units Shipped: 9/9/2021

Single Vial w/Carton Dimensions: 1.7”(d) x 1.8”(w) x 2.7”(h)
Single Vial w/Carton Weight: 2.1 oz.

Case: A full case contains 100 vials in cartons
Case Dimensions: 9.3”(d) x 18.9”(w) x 6.3”(h)
Case Weight: 13.3 lb.

Administration: (Detailed guidelines are available.)

Recommended Dilution and Administration Instructions for Bamlanivimab and Etesevimab for IV Infusiona in Patients Weighing 50 kg or More

Drug^a: Add 20 mL of bamlanivimab (1 vial) and 40 mL of etesevimab (2 vials) for a total 60 mL to an infusion bag and administer as instructed below. Note: not all 50 mL & 100 mL saline bags will allow addition of 60 mL of bamlanivimab/etesevimab – please ensure bag allows for mixing.

Recommended Dilution and Administration Instructions for Bamlanivimab and Etesevimab for IV Infusion in Patients Weighing LESS Than 50 kg

Drug^a: Add 20 mL of bamlanivimab (1 vial) and 40 mL of etesevimab (2 vials) for a total 60 mL to an infusion bag and administer as instructed below. Note: not all 50 mL & 100 mL saline bags will allow addition of 60 mL of bamlanivimab/etesevimab – please ensure bag allows for mixing.

Resources/Links:

• Lilly Bamlanivimab and Etesevimab webpage, including:
• FDA Letter of Authorization
• Fact Sheet for Healthcare Providers
• Fact Sheet for Patients, Parents and Caregivers (English)
• Fact Sheet for Patients, Parents and Caregivers (Spanish)
• Lilly Bamlanivimab and Etesevimab Antibody Playbook
• FDA Frequently Asked Questions on the EUA for Bamlanivimab and Etesevimab
• FAQ: Allocation, Distribution, and Administration of Bamlanivimab and Etesevimab

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^a. 700 mg of bamlanivimab and 1,400 mg of etesevimab are added to the same infusion bag and administered together as a single intravenous infusion.

^b. The minimum infusion time for patients weighing less than 50 kg who are administered bamlanivimab and etesevimab together using the 250 mL prefilled 0.9% Sodium Chloride infusion bag must be extended to at least 70 minutes to ensure safe use (endotoxin load).