Etesevimab Injection (700 mg/20 mL)
MUST ADMINISTER WITH BAMLANIVIMAB
Manufacturer: Eli Lilly and Company
Distributor: AmerisourceBergen (a.k.a., ABC);
c19therapies@amerisourcebergen.com
Product: Component of 2-drug monoclonal antibody cocktail for outpatient infusion
Emergency Use Authorization (EUA): 02/09/2021
Units:Supplied as one single-dose 20 mL vial per carton
Earliest Expiration Date of Units Shipped: 12/6/2021 |
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Storage: Keep in carton until use. Unopened vials must be stored at refrigerated temperature (2oC to 8oC/36°F–46°F) until use. Do not freeze, shake, or expose to direct light.
Single Vial w/ Carton Dimensions: 1.7”(d) x 1.8”(w) x 2.7”(h)
Single Vial w/ Carton Weight: 2.1 oz.
Case: A full case contains 100 vials in cartons
Case Dimensions: 9.3”(d) x 18.9”(w) x 6.3”(h)
Case Weight: 13.3 lb.
Bamlanivimab Injection (700 mg/20 ml)
Manufacturer: Eli Lilly and Company
Distributor: AmerisourceBergen (a.k.a., ABC);
c19therapies@amerisourcebergen.com
Product: Component of 2-drug monoclonal antibody cocktail for outpatient infusion & Single monoclonal antibody for outpatient infusion
Emergency Use Authorization (EUA): 02/09/2021 (2-drug cocktail); 11/9/2020 (single agent)
Units: Supplied as one single-dose 20-ml vial per carton
Earliest Expiration Date of Units Shipped: 9/9/2021 |
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Storage: Keep in carton until use. Unopened vials must be stored at refrigerated temperature (2oC–8oC / 36°F–46°F) until use. Do not freeze, shake, or expose to direct light.
Earliest Expiration Date of Units Shipped: 9/9/2021
Single Vial w/Carton Dimensions: 1.7”(d) x 1.8”(w) x 2.7”(h)
Single Vial w/Carton Weight: 2.1 oz.
Case: A full case contains 100 vials in cartons
Case Dimensions: 9.3”(d) x 18.9”(w) x 6.3”(h)
Case Weight: 13.3 lb.
Administration: (Detailed guidelines are available.)
Recommended Dilution and Administration Instructions for Bamlanivimab and Etesevimab for IV Infusiona in Patients Weighing 50 kg or More
Druga: Add 20 mL of bamlanivimab (1 vial) and 40 mL of etesevimab (2 vials) for a total 60 mL to an infusion bag and administer as instructed below. Note: not all 50 mL & 100 mL saline bags will allow addition of 60 mL of bamlanivimab/etesevimab – please ensure bag allows for mixing.
Size of prefilled 0.9% Sodium
Chloride infusion bag |
Maximum Infusion Rate |
Minimum Infusion Time |
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50 mL | 310 mL/hr | 21 minutes |
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100 mL | 310 mL/hr | 31 minutes |
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150 mL | 310 mL/hr | 41 minutes |
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250 mLb | 310 mL/hr | 60 minutes |
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Recommended Dilution and Administration Instructions for Bamlanivimab and Etesevimab for IV Infusion in Patients Weighing LESS Than 50 kg
Druga: Add 20 mL of bamlanivimab (1 vial) and 40 mL of etesevimab (2 vials) for a total 60 mL to an infusion bag and administer as instructed below. Note: not all 50 mL & 100 mL saline bags will allow addition of 60 mL of bamlanivimab/etesevimab – please ensure bag allows for mixing.
Size of prefilled 0.9% Sodium
Chloride infusion bag |
Maximum Infusion Rate |
Minimum Infusion Time |
---|
50 mL | 310 mL/hr | 21 minutes |
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100 mL | 310 mL/hr | 31 minutes |
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150 mL | 310 mL/hr | 41 minutes |
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250 mLb | 266 mL/hr | 70 minutes |
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Resources/Links:
a. 700 mg of bamlanivimab and 1,400 mg of etesevimab are added to the same infusion bag and administered together as a single intravenous infusion.
b. The minimum infusion time for patients weighing less than 50 kg who are administered bamlanivimab and etesevimab together using the 250 mL prefilled 0.9% Sodium Chloride infusion bag must be extended to at least 70 minutes to ensure safe use (endotoxin load).