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  •  DNA

    Review and Revision of the Screening Framework Guidance for Providers of Synthetic Double-Stranded DNA

    ASPR is soliciting feedback on whether and, if so, how the Screening Framework Guidance for Providers of Synthetic Double-Stranded DNA should be modified to address new and emerging challenges. We are seeking public input on changes that would either expand or limit the following areas: scope of the Guidance; sequence screening; biosecurity measures; customer screening; minimizing burden of the Guidance; technologies subject to the Guidance; and comments on other related issues. The deadline for public comments is October 25

    Learn More and Submit Comments

  •  H5N1.  Image courtesy of CDC Public Health Image Library

    NIH commitment to transparency on research involving potential pandemic pathogens

    NIH takes the need to ensure the safety of the public very seriously. We believe the HHS Framework process strikes the right balance of rigorous oversight with the advancement of the important science necessary to prevent and treat infectious diseases.

    View the NIH statement

  •  lab tech

    Two Research Projects Reviewed Under Department of Health and Human Services Framework for Guiding Funding Decisions about Proposed Research Involving Enhanced Potential Pandemic Pathogens

    Under the HHS P3CO Framework, the HHS P3CO Review Group determined that, in the case of both research proposals, the research is acceptable for HHS funding with recommended changes to increase the potential benefits while decreasing risks; suggested changes were included as terms and conditions of the awards.

    Learn more about the approval

  •  lab worker

    NIH Lifts Funding Pause on Gain-of-Function Research

    The National Institutes of Health announced that it is lifting a funding pause dating back to October 2014 on gain-of-function (GOF) experiments involving influenza, SARS, and MERS viruses.

    Read the NIH Director's Statement

  •  lab hood

    Notice Announcing the Removal of the Funding Pause for Gain-of-Function Research Projects

    The National Institutes of Health has removed the funding pause on the provision of new or continuation funding for gain-of-function research projects.

    Read the Official Notice


About Science Safety Security


Welcome to the S3: Science, Safety, Security website! Safe and successful scientific research protects the nation and the world from infectious diseases, terrorism, and environmental changes. This research ranges from discovering new antibiotics to investigating ways to make crops more drought resistant. Dedicated scientists conduct this research all over the country and the world in highly sophisticated laboratory facilities. The resources provided here will give you an introduction to Biorisk Management, which includes biosafety, biosecurity, biocontainment, and other topics related to biological organisms.

The Law & Policy section will give you a clear understanding of the many laws, regulations, policies, and guidance documents that exist around Biorisk Management. The Dual Use Research of Concern section contains the recent United States Government policies, recommendations, and educational materials on dual use research of concern. The S3 Newsletter provides news from around the government on biorisk management activities, conference summaries, and upcoming events.

Come back regularly for additional materials and new topics. If you have suggestions for topics you would like to see covered, contact us​ and let us know!